The well-known natives and residents of Amersham include:

• William HAKEWILL (1574-1655), legal antiquary who regained rights to send members to Parliament for Amersham, Wendover and Marlow. M.P. for Amersham.
• John GREGORY (1607-1646), orientalist and author.
• Edmund WALLER (1606-1687), poet and politician.
• Isaac PENNINGTON (1616-1679), puritan and quaker.
• Robert WHITEHALL (1625-1685), poetaster.
• Thomas ELLWOOD (1639-1713), Quaker and friend of Milton.
• Sir Samuel GARRARD (1650-1724), Lord Mayor of London and M.P. for Amersham.
• John Evan HODGSON (1831-1895), painter and artist.
• Charles Frederick TYRWHITT DRAKE (1846-1874), naturalist and explorer in the Holy Land. Co-author on works of exploration with Sir Richard Burton in Syria.
• Arthur Llewelyn JONES-MACHEN (1863-1947), author and essayist.
• Joshua Edward Synge COOPER (1901-1981), cryptanalyst, linguist, and intelligence officer, responsible for much of the work on decoding at Bletchley Park during the 2nd World War.
• Reginald Edward MANNINGHAM-BULLER (1905-1980), fourth baronet, and first Viscount Dilhorne. Conservative M.P. and Attorney General in Conservative administrations from 1954 to 1962.
• Sir Alexander HADDOW (1907-1976), experimental pathologist and pioneer in the field of cancer treatment.
• Kenneth Page OAKLEY (1911-1981), anthropologist and head of the anthopology department in the Natural History Museum.
• Sir Michael DENISON (1915- 1998), actor.
• Dulcie GRAY (1920- ), actress and playwright.

• Names from the Autobiography of the Rev. William Gill (b. Totnes, Devon, 1813), extracted by Mike Foster.

• Dictionary of National Biography Index and Epitome, ed. Sir Sidney Lee (1903), based on the 63-volume work. It's part of the Bolles London Collection in the Perseus Project, Tufts University in Massachusetts. This volume, with 30,378 biographical entries on English, Welsh, Scottish, and Irish notables up to the late 19th century, grew into today's three-volume Concise DNB, and the entire DNB is now being revised by Oxford University Press. (Users with a UK public library card can access the current DNB at http://www.oxforddnb.com/.)
• The BBC's Memoryshare website (archived copy) is "a living archive of memories from 1900 to the present day [to which readers] can contribute, share and browse memories of life experiences and see them in the context of recent and historical events.".
• The Methodist Archives - Index of Methodist ministers.
• Searchable Index to Who Was Who 1897-1916,  provided by UK Genealogy Archives.